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Monitor Closely (2)diazepam will raise the amount or effect of midazolam intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism.apalutamide will lower the extent or outcome of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with